Girlfriend and I vacationed in Hyannis last year. Great place to visit and I really got into fishing during that trip. We took a headboat out of Hyannis Harbor for fluking trip. Good time and I can't wait to get up there again with a little more fishing know-how under my belt!
Buzzards Bay lies a little to the west of Hyannis, but that whole area is so rich with fisherman and all manners of nautical things. New Bedford has a long history of being a whaling town. Also, the Woods Hole Oceanographic Institute is located nearby. We really wanted to visit, but just didn't have the time.